CLDN8 and human papilloma virus infection: The most significantly enriched gene-based pathways were the human papillomavirus infection (ssc05165) with five genes (i.e., CCND2, CTNNB1, JAK1, LAMC1, and NFKB1), followed by the PI3K-Akt signaling pathway (ssc04151) with five genes (i.e., CCND2, F2R, JAK1, LAMC1, and NFKB1) and the hepatitis C (ssc05160) with four genes (i.e., CLDN8, CTNNB1, JAK1, and NFKB1) (Figure 4A).