PRKAA1 and pulmonary arterial hypertension: These possibilities again receive indirect support from studies on Andeans if, as suspected, cell-specific AMPK-α1 repression is delivered through identified SNPs in PRKAA1 [94], because Andeans not only enter relative hypoventilation during exercise at altitude [95], but also exhibit attenuated HPV with postnatal persistence of pulmonary hypertension [95].