FBXW7 and diffuse large B-cell lymphoma: In addition, in ~43% of individuals with diffuse large B cell lymphoma (DLBCL) positive for nonsense or missense mutations of MYC, the mutations are located in the CPD sequence [67], suggesting that impaired degradation of c-Myc by FBXW7 is a key mechanism underlying c-Myc accumulation in DLBCL.