FBXW7 and acute lymphoblastic leukemia: Activating mutations of NOTCH1 have thus been identified in ~50% to 60% of T-ALL [82] and precursor T-LBL [83,84] cases, and ~10% of these mutations affect the codon for Pro2514 in the CPD of the encoded protein and are predicted to abrogate the interaction with FBXW7.