APP and Alzheimer disease: For example, hsa-miR-106, hsa-miR-153, and hsa-miR-101 have been shown to modulate APP [40,41,42], while beta secretase 1 (BACE1) has been shown to be targeted by hsa-miRNA-29 and hsa-miR-107, linking miRNAs to the regulation of amyloid production in AD brains [43].