Expression casein kinase 2, beta polypeptide (CSNK2B), apolipoprotein J (APOJ), and tissue inhibitor of metalloproteinase 3 (TIMP3) interleukin-1 receptor-associated kinase 1 (IRAK1) were both upregulated in both AD-NFT and AD-non-NFT neurons compared to normal neurons. The gene discussed is TIMP3; the disease is Alzheimer disease.