Several low penetrant common risk variants and rare mutations were also discovered, which could also impact the risk of AD or act as risk modifiers, such as clusterin (CLU), SORL1, ABCA7, Siglec-3 (CD33), Phospholipase D Family Member 3 (PLD3), Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM), NME/NM23 Family Member 8 (NME8), TREM2, A-Kinase Anchoring Protein 9 (AKAP9), or A Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) [4,5,6,7,8]. This evidence concerns the gene CLU and Alzheimer disease.