Neuropathological changes in the AD brain include progressive hippocampal and cortical atrophy, visible upon neuroimaging and macroscopic examination, suggesting intracellular neurofibrillary tangles (NFTs) of the hyperphosphorylated tau protein and extracellular depositions of amyloid-β (Aβ)1–42 peptide accompanied by neuronal and synapse loss and reactive gliosis [1]. Here, MAPT is linked to Alzheimer disease.