Table 1 introduces several miRNAs involved in different AD-associated mechanisms, including amyloid metabolism, Tau pathology, immune mechanism, or cell death. MiRNAs in biofluids (blood, plasma, serum, saliva) were believed to be promising markers for AD diagnosis [44]. For better understanding of the disease mechanisms and for early detection and diagnosis of AD, the generation of miRNA panel should be critical (Figure 2). The gene discussed is MAPT; the disease is Alzheimer disease.