The main effects of stress on intestinal physiology are already the subject of many excellent reviews [62,80] and the participation of NPs, e.g., Corticotropin-releasing Hormone/Factor (CRH/CRF), NT, SP and VIP, in the pathogenesis of IBD is underlined [52,58,79,81,82,83,84]. The gene discussed is TFF2; the disease is inflammatory bowel disease.