Many steps of CRC promotion, progression and liver metastasis are connected to the activity of pro-inflammatory (CRHR1, NPY, NT), anti-inflammatory (CGRP, CRHR2, VIP) or dual role (SP) NPs, regulation of the local immunological profile (CRH/CRHRs), dysfunctions of the protective/enterotrophic role of NPs on epithelial cells (NT/NTSR system), structural-functional changes in ENS innervation of the large intestine in CRC (including PNI), or other tumor-promoting factors (bacterial GIT infections, such as H. pylori). This evidence concerns the gene NPY and neoplasm.