Methylation of the NTSR1 promoter in some human CRC cells (KM12c, Caco2 and DLD1) and NTSR2 in all six CRC cell lines (KM12c, Caco2, DLD1, HT-29, HCT116 and SW480) was also noted [157]. Here, NTSR2 is linked to colorectal carcinoma.