AKT1 and colorectal carcinoma: According to some reviews, the NT/NTSR1 system regulates different steps of CRC metastasis through three main signaling pathways (IP3/Ca2+/PKC/MAPKs, MMPs/EGFR/MAPKs (PI3K/AKT), or Rho-GTPases and non-receptor tyrosine kinase pathways [149]).