CRHR2/Ucn2 signaling inhibits tumor growth and metastasis through downregulation of endogenous IL-6/IL-6R expression, reduction of STAT3 phosphorylation mediated by this cytokine, as well as inhibition of STAT3 in CRC cells, resulting in a block of expression of genes regulated by STAT3, as well as inhibition of cell cycle and EMT [96,98]. The gene discussed is STAT3; the disease is colorectal carcinoma.