Probes corresponding to the following 10 genes were significantly associated with AD in both blood-based and brain-specific analyses (Table 1 and Table 2): NANOS2 (plan 2), HLA-DQB2 (plan 3), FAM193B (plan 4), SLC6A7, BPGM, PSTK, KRTAP5-11, LECT1, ZNF598, and C16orf80 (plan 5). The gene discussed is HLA-DQB2; the disease is Alzheimer disease.