AD-associated SNPs with PGWAS < 5E-08 were not found within ±1 Mb flanking regions of these probes in our meta-analyses or other studies in GWAS databases [4,5], although several SNPs with 5E-08 ≤ PGWAS < 5E-06 were previously reported within ±1 Mb of probes corresponding to AIM2 [74] and C16orf80 [75,76]. The gene discussed is AIM2; the disease is Alzheimer disease.