Hypermethylated regions overlapping DUSP22 gene were previously detected in entorhinal and dorsolateral prefrontal cortices and/or hippocampus of AD affected individuals [18,19], and CpG hypermethylation of SORBS3 was detected in the cerebral cortex of AD patients and transgenic AD mouse models [11,20]. This evidence concerns the gene DUSP22 and Alzheimer disease.