SOX7 and metastatic neoplasm: HepG2 cells were cultured in the presence of doxorubicin and sorafenib and the resultant chemoresistant stem-like cells, capable of generating hepatospheres and metastatic tumors in mice, showed increased expression of miR-452 which targeted SRY-box transcription factor 7 (SOX7) that inhibits Wnt/β-catenin signaling pathway [178].