Additional targets of miR-22, identified in human HCC cells include the pro-apoptotic Bcl-2 homology 3 (BH3)-only protein BCL2 modifying factor (BMF), cyclin dependent kinase inhibitor 1C (CDKN1C/p57), and histone deacetylase 6 (HDAC6), mediating its oncogenic function [87,88,89]. The gene discussed is HDAC6; the disease is hepatocellular carcinoma.