AKT1 and hepatocellular carcinoma: miR-375 targets the oncogene AEG-1/MTDH, a potent inducer of chemoresistance, and miR-375 and doxorubicin, co-loaded onto lipid-coated calcium carbonate nanoparticles, markedly inhibited xenograft growth of doxorubicin-resistant HepG2 cells as well as primary tumor growth in an Akt/Ras-induced HCC model [182].