Argonaute crosslinking immunoprecipitation (Argonaute-CLIP) sequencing identified the RNA interactome of miR-21 identifying novel targets, such as Calmodulin regulated spectrin associated protein 1 (CAMSAP1), DEAD-box helicase 1 (DDX1), and Myristoylated alanine rich protein kinase C substrate like 1 (MARCKSL1), the expressions of which correlated with HCC patient survival, and also identified required for meiotic nuclear division 5 homolog A (RMND5A), an E3 ubiquitin ligase, as a miR-21 target, suggesting a widespread gene expression regulation by miR-21 [84]. The gene discussed is RMND5A; the disease is hepatocellular carcinoma.