MTOR and hepatocellular carcinoma: Upregulated expression of MALAT1 was found in human HCC, and it was shown that MALAT1 functions as a proto-oncogene by upregulating serine and arginine rich splicing factor 1 (SRSF1) resulting in alternative splicing of several genes, such as ribosomal protein S6 kinase B1 (RPS6KB1), leading to activation of the mammalian target of rapamycin (mTOR) signaling and Wingless/Integrated (Wnt)/β-catenin pathway [24].