CCN2 and systemic sclerosis: Comprehensive meta-analysis identified several functional single nucleotide polymorphisms (SNPs) in the non-coding regions of the CCN2/CTGF gene increasing risk of abdominal aortic aneurysm [82], systemic sclerosis [83], nephropathy in type I diabetes [84], calcified aortic stenosis [85], and even human longevity [86].