CCN2 and neoplasm: Meanwhile, CCN2/CTGF is also a predicted and validated target of the miR-17-92 microRNA cluster that regulates tumor neovascularization, miR-146a-5p that suppresses angiogenesis and promotes joint stiffness [114], and the circular RNA circSlc8a1, which functions as an endogenous sponge for miR-133a, attenuating mechanical overload [115].