In contrast, MT3 facilitates the access of H. capsulatum to labile Zn pools in macrophages, inadvertently leading to fungal Zn acquisition and persistence (Chowdhury et al., 2019, Subramanian Vignesh et al., 2016) Therefore, our data further highlight the function of MT1 and MT2 as central hubs that control the bidirectional Zn shuttling into or out of phagolysosomes during fungal infections. This evidence concerns the gene MT3 and fungal infectious disease.