,7The cellular and molecular mechanisms that might explain obesity and periodontitis relationship are systemic inflammatory changes in tumor necrosis factor (TNF)-α, Interleukin-6 (IL-6), oxidative stress, and adiponectin and leptin levels, which may result in greater susceptibility to chronic inflammatory diseases and infections.8 The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.