We demonstrate in our studies that this novel NOX1 mAb effectively detects NOX1 protein expression over a wide dynamic range, from a genetically-engineered cell clone that expresses large quantities of NOX1, to colon cancer cell lines with more modest endogenous NOX1 expression levels, and to a large array of human epithelial cancer specimens that vary dramatically in their expression of NOX1. Here, NOX1 is linked to colonic neoplasm.