Observing no obvious correlation in this initial data set between RAS mutation status and NOX1 overexpression (Fig 4A), 27 colon cancer cell lines from the ATCC, 62 CRC cell lines from the Cancer Cell Line Encyclopedia (CCLE), and 623 colorectal tumor samples plus 51 normal colon specimens from The Cancer Genome Atlas (TCGA) were subsequently evaluated. Here, NOX1 is linked to cancer.