In contrast, our analyses revealed that the distribution of NOX1 staining was significantly different between normal colon mucosa and colon lesions (***p<0.001 for colon carcinomas and adenomas; *p<0.05 for colon polyps), as well as in small intestinal carcinomas relative to normal small intestinal tissue (*p<0.05, Table 3). This evidence concerns the gene NOX1 and adenoma.