The specificity of our novel mouse mAb was further demonstrated by its lack of cross-reactivity with NOX1 homologs NOX2, NOX4, NOX5, and DUOX2 in relevant cell lines and systems: HEK293 clones stably overexpressing NOX1, NOX2, NOX4, or NOX5, and DUOX2-expressing BxPC-3 pancreatic cancer cells untreated or treated with 25 ng/ml IL-4 for 24 h (Fig 1F). Here, NOX4 is linked to familial pancreatic carcinoma.