In LS513 colon cancer cells that endogenously express NOX1, the NOX1 band was also detected in lysate from the membrane fraction (S3B Fig, left), and the intensity of the immunoreactive band was strongly attenuated in LS513 cells transfected with NOX1 siRNA (S3B Fig, right). The gene discussed is NOX1; the disease is malignant colon neoplasm.