On the other hand, we have demonstrated significant overexpression of NOX1 mRNA in tumor specimens with both KRAS wild type (1.6-fold increase, *p<0.05), and KRAS mutant (1.9-fold increase, ***p<0.001) genotypes when these CRCs are compared to specimens of normal colonic mucosa derived from the TCGA cohort (Fig 4). Here, NOX1 is linked to neoplasm.