Additionally, some cancer-related pathways in the late stages are more significant than in the early stages, such as PI3K-Akt signaling pathway, focal adhesion, gap junction, transcriptional misregulation in cancer, proteoglycans in cancer, Rap1 signaling pathway, microRNAs in cancer, EGFR tyrosine kinase inhibitor resistance, and circadian entrainment. This evidence concerns the gene AKT1 and cancer.