Genes up-regulated in common in advanced human liver fibrosis and in Ezh1/2-KO mouse liver include biomarkers of liver disease (e.g. Golm1) [60] and genes that play a fundamental role in liver fibrogenesis and HCC (e.g., Spp1/Osteopontin) [61]. This evidence concerns the gene SPP1 and Hepatic fibrosis.