EZH1 and Hepatic fibrosis: The combined deficiency of Ezh1/Ezh2 in mouse liver is reported to induce premature differentiation of perinatal hepatocytes, with 2 week postnatal Ezh1/Ezh2-deficient mice showing early increases in expression (early maturation) of a subset of genes not normally induced until 2 months of age in wild-type mice, including genes that regulate liver fibrosis [48].