APOE and early-onset autosomal dominant Alzheimer disease: For Alzheimer’s disease, our estimate of the liability-scale SNP heritability for the full 2013 dataset [39] is 15% for prevalence of 14% for those aged 71 older, half from APOE, while the recent “M2” and “M3” models of Zhang et al [14] gave values of 7% and 10% respectively–see S1 Appendix (p. S13).