When RA patients were stratified by ESR values (ESR ≧ 28 mm/hr vs. ESR < 28 mm/hr, indicating high vs. low ESR, respectively, as described in Methods)22, the correlation coefficient between DAS28-MCP-1 score and DAS28-ESR score increased to 0.949 for 835 visits and to 0.940 at baseline (Table 2). The gene discussed is CCL2; the disease is rheumatoid arthritis.