We found that SH3RF3 could interact with all three JIP family members JIP1, JIP2, and JIP3 in 293T (Fig. 7c and Supplementary Fig. 5c); however, JIP3 was the only JIP gene expressed in breast cancer cells MCF10AT (Supplementary Fig. 5d). Here, MAPK8IP3 is linked to breast carcinoma.