However, multiple regression analysis adjusted for age and sex revealed a significant association of CDH6 CSF levels with both p-tau (β = 23.2, SE = 3.4, P = 3.48 × 10−11) and t-tau (β = 207.4, SE = 36.4, P = 2.40 × 10−8) when pooling AD patients and controls (Table 3 and Fig. 3). Here, CDH6 is linked to Alzheimer disease.