The following potential proteases for the different CKD aetiologies were identified: ADPKD (MMP7), MCD (CTSB, CTSD, CTSE, MEP1A, MMP7, PGA3), MGN (MMP3, MMP7, MMP9, MMP13, MMP14), IgAN (MMP7), FSGS (MMP3, MMP7), vasculitis (PGA3), nephritis (MMP7, MMP9), nephrosclerosis (MMP7), and DKD (MMP9). The gene discussed is PGA3; the disease is nephrosclerosis.