The following potential proteases for the different CKD aetiologies were identified: ADPKD (MMP7), MCD (CTSB, CTSD, CTSE, MEP1A, MMP7, PGA3), MGN (MMP3, MMP7, MMP9, MMP13, MMP14), IgAN (MMP7), FSGS (MMP3, MMP7), vasculitis (PGA3), nephritis (MMP7, MMP9), nephrosclerosis (MMP7), and DKD (MMP9). This evidence concerns the gene MMP3 and autosomal dominant polycystic kidney disease.