The following potential proteases for the different CKD aetiologies were identified: ADPKD (MMP7), MCD (CTSB, CTSD, CTSE, MEP1A, MMP7, PGA3), MGN (MMP3, MMP7, MMP9, MMP13, MMP14), IgAN (MMP7), FSGS (MMP3, MMP7), vasculitis (PGA3), nephritis (MMP7, MMP9), nephrosclerosis (MMP7), and DKD (MMP9). The gene discussed is MEP1A; the disease is chronic kidney disease.