In this study, we investigated the 3D chromatin organisation of the 11p15.5 imprinted region in cells from healthy individuals and from patients with BWS and SRS, and found that profound alterations in the chromatin architecture of the IGF2/H19 and CDKN1C/KCNQ1OT1 regions characterise both imprinting disorders. This evidence concerns the gene CDKN1C and Silver-Russell syndrome.