Interestingly, acute treatment of multiple AR-proficient prostate cancer cell lines with any of the AR inhibitors was sufficient to modulate DECR1 expression (Fig. 5c) and transient silencing of DECR1 potentiated the effect of enzalutamide in C4-2 cells, a CRPC derivative of LNCaP (Fig. 5d). This evidence concerns the gene AR and Familial prostate cancer.