It has been reported that the HIV virus indirectly impairs nitric oxide and lysozymes production and IgA synthesis and secretion by the oral mucosa that normally function as bactericidal, fungicidal, and viricidal agents leading to OHL.12 Most recently, it has been suggested that HIV impairs the oral mucosal barrier in addition to suppressing CD4+ T cells by also suppressing the Th17 T-cells, which secrete IL-17 and IL-23 cytokines, which further weakens the oral mucosal immunity and predisposes it to opportunistic infections.12,13. Here, CD4 is linked to Opportunistic infection.