On the contrary, several reports showed that XRCC1 was down-regulated in glioma, bladder cancer, pancreatic cancer, and gastric cancer (Crnogorac-Jurcevic et al., 2002; Sak et al., 2005; Wang et al., 2012; Mei et al., 2019). This evidence concerns the gene XRCC1 and central nervous system cancer.