In this study, we observed that XRCC1 expression was up-regulated in GBC compared with non-tumor tissues, which was consistent with previous studies where XRCC1 was overexpression in ovarian cancer and head and neck squamous cell cancer (Ang et al., 2011; Abdel-Fatah et al., 2013). The gene discussed is XRCC1; the disease is ovarian carcinoma.