DHODH and cancer: As cytosolic reactive oxygen species are formed most notably through NADPH oxidases (NOX) activity and influence metabolic processes including glycolysis and downstream oxidative phosphorylation (Forrester et al., 2018), inhibition of DHODH is also discussed to have an influence on NOX activity mainly in the context of cancer e.g., in transformed skin cells, ROS production was reduced after incubation with teriflunomide (Hail et al., 2010).