While anti-DFS70/LEDGF antibodies could be involved in association of the HS pattern with the lower prevalence of cancer, anti-Scl70 and anti-RNAP-III antibodies, the latter being frequently associated with the presence of anti-RNAP-I, are good candidates for the association between ANoA and the presence of cancer, because these antibodies are well known to be associated with cancer and possibly give rise to a nucleolar pattern. Here, FDXR is linked to cancer.