PIN1 and cancer: Pin1 overexpression or its over activation can be inhibited by genetic approaches or chemically with juglone (Hennig et al., 1998), all-trans retinoic acid (ATRA; Toledo et al., 2011) or KPT-6566 (Campaner et al., 2017) and, when tested, Pin1 inhibitors were able to suppress cancers (Estey et al., 1997; Budd et al., 1998; Shen et al., 2004; Lu and Hunter, 2014; Wei et al., 2015; Zhou and Lu, 2016; Lian et al., 2018).