In addition, the top three pathways associated with the DEGs of sorted B-cells from SLE patients were mostly enriched in oxidative stress- and ROS-induced cellular signaling (Figure 6A), chemotaxis and lysophosphatidic acid signaling via GPCRs (Figure 6B), and androgen receptor activation and downstream signaling in prostate cancer (Figure 6C). Here, AR is linked to systemic lupus erythematosus.