FOSB and systemic lupus erythematosus: We noticed that, all the DERNAs enriched in systemic lupus erythematosus and alcoholism pathways were up-regulated, except for gene 2354, whose gene symbol is “FOSB.” Gene annotation of FOSB shows that it was a proto-oncogene, and it has been implicated as regulators of cell proliferation, differentiation, and transformation.