The results showed that socioeconomic status (low or moderate income vs. high income, HR = 4.11, p = 0.18), serum albumin level (<35 vs. ≥35 g/L, HR = 9.11, p = 0.001), serum prealbumin level (<200 vs. ≥200 mg/L, HR = 4.47, p = 0.001), preoperative neutrophil count (<2.0*109/L vs. ≥2.0*109/L, HR = 4.48, p = 0.004), PNI (<51.2 vs. ≥51.2, HR=8.39, p = 0.005), differentiation (poor vs. high/moderate, HR = 3.98, p = 0.009) and lymph node metastasis (yes vs. no, HR = 3.48, p = 0.028) were significantly associated with ≥ grade 3 neutropenia in cycle 1. Here, TTR is linked to metastatic malignant neoplasm in the lymph nodes.