In the multivariate survival analysis, prealbumin, preoperative neutrophil count and PNI were identified as independent risk factors associated with ≥ grade 3 neutropenia in cycle 1 of adjuvant chemotherapy, with the hazard ratio (HR) of 2.89 (p = 0.041, 95%CI 1.05–7.99), 5.00 (p = 0.007, 95%CI 1.54–16.25), and 4.76(p = 0.049, 95%CI 1.01–22.49) respectively. This evidence concerns the gene TTR and Decreased total neutrophil count.