Other characteristic HNSCC mutations such as loss of 4q35.1 (FAT1) (1, 31), 5q35.2 (NSD1) (1, 31), LOH of 17p13.2 (TP53) (1, 31), and amplification of 7p11.2 (EGFR) (1, 31), 8q24.21 (MYC) (1, 25, 32) and 11q13.3 (CCND1, FADD, CTTN) (1) were detected in three tumors. The gene discussed is FAT1; the disease is head and neck squamous cell carcinoma.