FHIT and head and neck squamous cell carcinoma: Tumor 4 showed amplification of PIKC3A, SOX2, TP63, EGFR, PTK2, NOTCH 1, 2 & 3, AJUBA, TRAF3, ERBB2, MYC, and KMT2D, loss of CDKN2A, FAT1, APC, RB1, KLK12, SMAD4, and PTEN, and LOH of FHIT, CDKN2A, CASP8, TP53 and NFE2L2, which have all been reported in HNSCC (1, 13).