Tumor 4 showed amplification of PIKC3A, SOX2, TP63, EGFR, PTK2, NOTCH 1, 2 & 3, AJUBA, TRAF3, ERBB2, MYC, and KMT2D, loss of CDKN2A, FAT1, APC, RB1, KLK12, SMAD4, and PTEN, and LOH of FHIT, CDKN2A, CASP8, TP53 and NFE2L2, which have all been reported in HNSCC (1, 13). Here, SMAD4 is linked to head and neck squamous cell carcinoma.