Tumor cells increase iron uptake through the upregulation of divalent metal transporter-1 (DMT1), transferrin/transferrin-receptor (Tf/TfR), and lipocalin-2/lipocalin-2receptor (Lcn-2/Lcn-2R) systems, and its storage by ferritin (FT) heavy chain (FTH) and FTL overexpression (48, 57). The gene discussed is TFRC; the disease is neoplasm.