Examples of upregulated ECM components in cancer include collagens, non-collagen glycoproteins (FN, tenascin C, periostin), proteoglycans (biglycan, decorin), ECM regulators (cathepsin B, LOXL), and secreted factors (TGF-β1) [reviewed in (7)], to name only a few. This evidence concerns the gene FN1 and cancer.