Hsa_circ_0002375, hsa_circ_0111974, and hsa_circ_0081534 are spliced from KIT ligand (KITLG), estrogen related receptor gamma (ESRRG), and EPH receptor B4 (EPHB4), respectively, which play an essential role in cancer proliferation, metastasis and apoptosis. The gene discussed is EPHB4; the disease is cancer.