However, another one carried out on resistance to chemotherapy and the ATP binding cassette transporter P-glycoprotein, which is encoded by ABCB1 gene, has shown that 3D ECM is able to increase sensitivity of primary colon carcinoma cells to chemotherapy by affecting the cell polarity and consequently the polarization of P-glycoprotein expression at the cell surface (39). The gene discussed is ABCB1; the disease is colon carcinoma.