The mRNA level of TBP-2 was induced by 5-FU (10 μM, ***P < 0.001, 100 μM, **P < 0.01) (Figure 5A), and the protein expression of TBP-2 was also induced by 5-FU (10 μM, 100 μM, *P < 0.05) (Figure 5B), which suggests that TBP-2 is also involved in the oncotherapy of 5-FU in lung cancer cells. Here, TBPL2 is linked to lung cancer.