At the global proteome level, among 3063 proteins identified from TMT-labeled samples, 99.8% of proteins were varied within two-fold between low and high AFP groups of paracancerous samples, and 98.2 and 95.5% of proteins were changed within 2-fold in low and high AFP tumor samples when compared with their corresponding paracancerous samples, respectively (Figure 3B). Here, AFP is linked to neoplasm.