It has been reported that MAPRE2 is overexpressed in hepatocellular carcinoma (35) and esophageal squamous cell carcinoma (36); thus, MAPRE2 might be involved in tumorigenesis and promotion of tumor cell growth through Wnt signaling pathway or Aurora-B activation (37, 38). The gene discussed is AURKB; the disease is esophageal squamous cell carcinoma.