The cytokines associated with severe CRS could be divided into four categories: T cell-activating cytokines (e.g., IL-6, IFN-γ, sIL-2Rα, sIL-6R, and GM-CSF), monocyte/macrophage-activating cytokines (e.g., IL-6, IL-1Ra, IL-10, IP-10, and sIL-6R), monocyte/macrophage-attracting chemokines (e.g., monocyte chemoattractant protein (MCP)-1, IP-10, and IL-8), and cytokines released after tissue damage (e.g., IL-6, IL-8, granulocyte Colony-Stimulating Factor (G-CSF, and GM-CSF) [24, 40, 41]. The gene discussed is CSF3; the disease is congenital rubella syndrome.