With plenty of candidates to choose from, the serum levels of IL-6 and IFN-γ in the first 24 h after CAR-T cell infusion in B-ALL patients have been reported as robust biomarkers of severe CRS and CRES by scientists from the Fred Hutchinson Cancer Research Center (FHCRC) [26, 68]. Here, IFNG is linked to congenital rubella syndrome.