Similarly to CRS, higher levels of inflammatory mediators, including IL-1, IL-6, IL-10, IL-2, IFN-γ, tumor necrosis factor (TNF)-α, GM-CSF, G-CSF, MCP-1, CRP, and ferritin, are associate with higher grade neurotoxicity [22, 25, 28, 37, 38, 40, 46, 68]. This evidence concerns the gene IL6 and congenital rubella syndrome.