On analyzing the individual tumor types separately, ERα expression significantly correlated with male gender (p=0.043) in PTC and multicentricity in PDTC (p=0.029), whereas ERβ with female gender in PDTC (p=0.014) and HER-2 with tumor size in FTC (p=0.014). This evidence concerns the gene ESR2 and thyroid cancer, nonmedullary, 2.