Both platelets and PAR4 have been implicated in kidney function and CKD pathogenesis (Lambert, 2016; Madhusudhan et al., 2016; Palygin et al., 2016), and renal disease patients are prone to bleeding and thrombotic events (Saheb Sharif-Askari et al., 2017). The gene discussed is F2RL3; the disease is kidney disorder.