We first used bioinformatics analysis to find that both miRNA-126 and miRNA-28-3p may be involved in the insulin signaling pathway and the IGF signaling pathway (insulin/IGF pathway) and MAPK signaling pathways, and it can be speculated that miRNA-126 and miRNA-28-3p may cause DM through regulation of insulin signaling pathways and other related signaling pathways and target genes. This evidence concerns the gene INS and diabetes mellitus.