Moreover, specific IgE levels to the nematode specific marker ABA-1 were directly correlated with histone acetylation levels in CHI3L1, affecting H4Ac (rho 0.38, p = 0.01) and H3Ac (rho 0.33, p = 0.03), supporting that epigenetic changes in these loci were induced by the infection with this nematode. This evidence concerns the gene IGHE and infection.