MALT1 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: Genetic deletion of CARD11, BCL10, or MALT1, as well as the genetic inactivation of the MALT1 protease selectively in Foxp3+ Tregs was associated with Treg dysfunction in vivo and development of an IPEX-like disease (26, 28, 29).