Pro-inflammatory cytokine (IL-1β, IL-6, IFN-γ, TNF-α, and IL-12) expression was upregulated in untreated PBMCs of CRC patients when compared to healthy controls (UICC I–II: IL-1β, IL-6, IFN-γ: p < 0.001, TNF-α, IL-12: p < 0.01, UICC III–IV: IL-1β, IL-6, IFN-γ, TNF-α, IL-12: p < 0.001). Here, TNF is linked to colorectal carcinoma.