Incubation of PBMCs from UICC stage I–III CRC patients with KMP01D and the combination of KMP01D and vitamin D3 decreased IL-1β, IL-6, IFN-γ, TNF-α, and IL-12 cytokine expression which was observed in parallel with decreased CD68, CD14, and TLR4 expression in these cells (UICC I–II: IL-1β, IL-6, IFN-γ, TNF-α, IL-12: p < 0.01, UICC III: IFN-γ, TNF-α, IL-12: p < 0.001 and IL-1β, IL-6: p < 0.05, UICC IV: IFN-γ, IL-12: p < 0.01; Table 1). The gene discussed is TNF; the disease is colorectal carcinoma.