Compared to the TNFRSF9– Treg population, the TNFRSF9+ population exhibited high levels of a set of 260 genes, including those performing immunosuppressive functions, further supporting the finding that TNFRSF9+ cells not only are antigen-experienced but also form the major population of functional tumor Tregs. This evidence concerns the gene TNFRSF9 and neoplasm.