Notably, the migration of Treg cells into tumor areas was reduced when the CCL5-CCR5 signaling was disrupted via the reduction of CCL5 production or systemic administration of the CCR5 inhibitor TAK-779 (110), suggesting that selective interventions with CCL5-CCR5 axis might represent a novel immunomodulatory strategy for NSCLC treatment. This evidence concerns the gene CCL5 and non-small cell lung carcinoma.