By establishing a murine intratibial model of cancer-associated bone resorption, Kim et al. (102) showed that Runt-related transcription factor 3 (RUNX3) silencing in NSCLC cells triggered cell proliferation, migration and invasion, accompanied by osteolytic lesions, by enhancing CCL5 levels, suggesting that CCL5 may be a potent promoter of NSCLC progression. Here, RUNX3 is linked to cancer.