Thereafter, one family with an NLRP1 mutation between the NACHT and LRR domains and one sporadic patient with an NLRP1 mutation in the FIIND domain were reported to have autoinflammation symptoms, including follicular keratosis in the skin, as well as polyarthritis (NAIAD), and those symptoms were responsive to IL-1 inhibition (33) (Supplementary Table 1). This evidence concerns the gene NLRP1 and polyarticular arthritis.