The KLICK syndrome phenotype, which is limited to the epidermis, is reminiscent of another group of diseases that are caused by mutations in the pyrin/leucine-rich repeat (LRR) domains of NLRP1, mutations that lead to multiple self-healing palmoplantar carcinoma (MSPC)/familial keratosis lichenoides chronica (FKLC); also, the PRAID phenotype is reminiscent of diseases that are caused by mutations in the NLRP1 gene causative of NLRP1-associated autoinflammation with arthritis and dyskeratosis (NAIAD)/juvenile-onset recurrent respiratory papillomatosis (JRRP) (32). The gene discussed is NLRP1; the disease is keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome.