IL17A and type 1 diabetes mellitus: The results indicated that the several metabolic functional pathways (Type I diabetes mellitus and Antigen processing and presentation and Pathways in cancer) and immune-related pathways (Th17 cell differentiation and IL-17 signaling pathway) predominated in Coli group, which may resulting in abnormal T cell glucose metabolism (Granados et al., 2017) and chronic inflammation (Joerger et al., 2016) in the host mice and may account for the poor efficacy of immunotherapy.