Our previous study found that Gegen qinlian decoction enhances antitumor effects and PD-1 antibody efficacy by tuning intestinal microbiota in the mouse CT26 tumor model, the mechanism may be that Gegen qinlian decoction affects this process by regulating the glycerophospholipid metabolic pathway, accompanied by the expression levels of IFN-γ and IL-2 in the tumor were elevated (Lv et al., 2019). This evidence concerns the gene PDCD1 and neoplasm.