After exclusion of PCOS cases with a family history of diabetes or hypertension or dyslipidemia, the phenotype-genotype correlations between the gene INSR and MS were still significant, whereas the correlation between THADA and MS was not significant (rs2059807, age-adjusted P = 0.005, OR = 1.43; rs12478601, age-adjusted P = 0.067, OR = 0.79). Here, INSR is linked to metabolic syndrome.