The four variants, rs12478601, rs2059807, rs4784165, and rs2479106 are located in the intron regions of THADA, INSR, TOX3, and DENND1A genes, respectively; thus, it is unclear how these SNPs might affect the gene expression or function to influence the PCOS phenotype. This evidence concerns the gene DENND1A and polycystic ovary syndrome.