Our group performed the first two genome-wide association studies (GWAS) in Han Chinese women and reported 11 susceptibility loci (15 risk variants) for PCOS (9, 10), including INSR, THADA, LHCGR, FSHR, C9orf3, DENND1A, YAP1, RAB5B, HMGA2, TOX3, and SUMO1P1. In this study, we conducted a phenotype-genotype correlation analysis to investigate the impact of these 15 SNPs on MS and IR in women with PCOS. This evidence concerns the gene DENND1A and polycystic ovary syndrome.