INSR and polycystic ovary syndrome: Using a dominant model, the rate of MS was significantly higher in the GG + AG group for rs2059807 in INSR than in the AA group (26.8 vs. 22.5%, P = 0.023, OR = 1.26, Table 3), even after adjustment for age (adjusted P = 0.023, OR = 1.27), indicating that the risk genotype of rs2059807 was robustly associated with MS in PCOS cases.