DENND1A and diabetes mellitus: After exclusion of subjects with a family history of diabetes, the phenotype-genotype correlations between gene TOX3 and IR were still significant, whereas the correlation between DENND1A and IR was not significant (rs4784165, age- and BMI-adjusted P = 0.031, OR = 1.28; rs2479106, age- and BMI-adjusted P = 0.053, OR = 0.81).