When only T1D patients were considered, up-regulation of the genes MAP1LC3C (P < 0.001), CDH6 (P = 0.02), GPNMB (P = 0.009), HS3ST2 (P = 0.01), PMP22 (P < 0.001), and PKD2L1 (P = 0.04), and down-regulation of the genes CYP4F22 (P < 0.001) and LYPD3 (P = 0.01) were observed in decliners in comparison to non-decliners (Supplemental Figure 3). The gene discussed is PKD2L1; the disease is type 1 diabetes mellitus.