We observed decreased expression of CYP4F22 mRNA in the decliner group; downregulation of CYP4A11 mRNA, another CYP4 isoform involved in 20-HETE generation, was already described in a gene expression profile of renal biopsies from patients with hypertensive nephropathy (27). The gene discussed is CYP4A11; the disease is hypertensive nephropathy.