We excluded five anemic RLS patients (Hb <113 g/L for women and Hb <131 g/L for men) who did not have evidence of iron deficiency (serum ferritin ≥ 75 μg/L as well as TIBC ≥ 20%, mean serum ferritin as 236.1 ± 119.3 μg/L). This evidence concerns the gene GSTM1 and Iron deficiency anemia.