Table 1), Plaven-Sigray et al. found very strong evidence of decreased levels of TSPO in their meta-analysis using single-participant data of second-generation tracer studies (18, 19). To date, 14 studies have measured TSPO tracer binding in schizophrenia-spectrum disorders, of which seven were conducted in patients within the first 5 years of diagnosis (cfr. Table 1). Three studies included at ultra-high risk for psychosis (2, 4, 10). We have previously highlighted variability in terms of study population, tracer, kinetic modeling, and outcome measures (1). Here, TSPO is linked to psychotic disorder.